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Moss Nutrition L-5-MTHF uses the natural S-isomer form of MTHF, offering high bioavailability, enhanced solubility, and exceptional stability. Each capsule contains 1 mg (1000 mcg) of methylfolate.


L-5-MTHF (methyltetrahydrofolate) is a bioactive and bioavailable form of folate (folic acid). It is considered the active form of folate because it is the form that is directly incorporated into the methylation cycle that converts homocysteine to methionine, among other functions.


Methylation is a key biological process that involves donating one methyl group (a single carbon atom bonded to three hydrogen atoms) to substrates such as DNA, RNA, proteins such as neurotransmitters, and individual protein amino acids.


Methylation also is an important step in detoxification processes within the body.

A significant number of people may have an enzyme defect (MTHFR mutation) or single nucleotide polymorphism (SNP) that reduces the ability of these individuals to convert folic acid and natural folates into their active form, methylfolate.


L-5-MTHF is a safe and effective way to increase the body's activated folate levels. During pregnancy, folate is well-known as a critical nutrient in helping to reduce the risk of neural tube defects in the developing fetus. 

Moss Nutrition L-5-MTHF - 120 caps

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